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| 1 | Cytoplasmic m6A reader YTHDF3 promotes mRNA translation显示文摘 | Ang Li Yu-Sheng Chen Xiao-Li Ping Xin Yang Wen Xiao Ying Yang Hui-Ying Sun Qin Zhu Poonam Baidya Xing Wang Devi Prasad Bhattarai Yong-Liang Zhao Bao-Fa Sun Yun-Gui Yang | 2017 | Cell Research2017，27，3： | 82 |
| 2 | 5-methylcytosine promotes mRNA export--NSUN2 as the methyltransferase and ALYREF as an m5C reader显示文摘 | Yang, Xin Yang, Ying Sun, Bao-Fa Chen, Yu-Sheng Xu, Jia-Wei Lai, Wei-Yi Li, Ang Wang, Xing Bhattarai, Devi Prasad Xiao, Wen Sun, Hui-Ying Zhu, Qin Ma, Hai-Li Adhikari, Samir Sun, Min Hao, Ya-Juan Zhang, Bing Huang, Chun-Min Huang, Niu Jiang, Gui-Bin Zhao, Yong-Liang Wang, Hai-Lin Sun, Ying-Pu Yang, Yun-Gui | 2017 | Cell Research2017，27，5： | 62 |
| 3 | 加氧灌溉对菠萝根区土壤呼吸和生理特性的影响显示文摘通过大田试验,研究了加氧灌溉对菠萝根区土壤呼吸作用、生理特性、生物量积累、果实产量、品质和水分利用效率的影响.采用Mazeei(空气注射器)给地下灌溉系统加入空气,设计了加氧和不加氧灌溉2种处理方式,7次重复.设计滴头埋深10 cm.研究表明,与对照相比,菠萝根区30 cm以内土壤水分质量分数和CO2质量分数没有明显差异,但是加氧灌溉使得土壤呼吸增加了100%;菠萝的果实鲜重、生物量鲜重、干物质重和收获指数明显增大,差异有统计学意义(p≤0.05);加氧灌溉提高了菠萝的水分生产率,与对照相比增加了17.2%;同时,加氧灌溉明显改善了菠萝单果尺寸和重量,使得单果重量增加了17.3%,田间产量增加了4.3%,增加了果实的糖质量分数,减少了果实的透明物.研究结果为加氧灌溉技术的推广应用提供了理论依据. | 陈新明 Jay Dhungel Surya Bhattarai Manouchehr Tobrabi Dayid J Midmore | 2010 | 排灌机械工程学报2010，28，6： | 43 |
| 4 | Oxygation Enhances Growth,Gas Exchange and Salt Tolerance of Vegetable Soybean and Cotton in a Saline Vertisol显示文摘Impacts of salinity become severe when the soil is deficient in oxygen.Oxygation(using aerated water for subsurface drip irrigation of crop) could minimize the impact of salinity on plants under oxygen-limiting soil environments.Pot experiments were conducted to evaluate the effects of oxygation(12% air volume/volume of water) on vegetable soybean(moderately salt tolerant) and cotton(salt tolerant) in a salinized vertisol at 2,8,14,20 dS/m ECe.In vegetable soybean,oxygation increased above ground biomass yield and water use efficiency(WUE) by 13% and 22%,respectively,compared with the control.Higher yield with oxygation was accompanied by greater plant height and stem diameter and reduced specific leaf area and leaf Na+ and Cl- concentrations.In cotton,oxygation increased lint yield and WUE by 18% and 16%,respectively,compared with the control,and was accompanied by greater canopy light interception,plant height and stem diameter.Oxygation also led to a greater rate of photosynthesis,higher relative water content in the leaf,reduced crop water stress index and lower leaf water potential.It did not,however,affect leaf Na+ or Cl- concentration.Oxygation invariably increased,whereas salinity reduced the K+:Na+ ratio in the leaves of both species.Oxygation improved yield and WUE performance of salt tolerant and moderately tolerant crops under saline soil environments,and this may have a significant impact for irrigated agriculture where saline soils pose constraints to crop production. | Surya P. Bhattarai David J. Midmore | 2009 | Journal of Integrative Plant Biology2009，51，7： | 22 |
| 5 | Controversies in diagnosis and management of Kawasaki disease显示文摘Kawasaki disease(KD) is a common medium vessel systemic vasculitis that usually occurs in small children. It has a predilection for the coronary arteries, but other medium sized arteries can also be involved. The etiology of this disorder remains a mystery. Though typical presentation of KD is quite characteristic, it may also present as incomplete or atypical disease in which case the diagnosis can be very challenging. As both incomplete and atypical forms of KD can be associated with serious coronary artery complications, the pediatrician can ill afford to miss these diagnoses. The American Heart Association has enunciated consensus guidelines to facilitate the clinical diagnosis and treatment of this condition. However, there are still several issues that remain controversial. Intravenous immunoglobulin remains the cornerstone of management but several other treatment modalities, especially glucocorticoids, are increasingly finding favour. We review here some of the contemporary issues, and the controversies thereon, pertaining to management of KD. | Rakesh Kumar Pilania Dharmagat Bhattarai Surjit Singh | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 16 |
| 6 | Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment显示文摘Tumor microenvironment(TME) comprising cellular and non-cellular components is a major source of cancer hallmarks.Notably, angiogenesis responsible for normal physiological remodeling process can otherwise harness vessel abnormalities during tumorigenesis eliciting severe therapeutic inefficiency. Currently, FDA approved antiangiogenic drugs have only shown modest clinical success owing to tumor hypoxia, antiangiogenic therapeutic resistance, and limited knowledge in understanding TME. In order to overcome these limitations, targeting angiogenesis combined with immunosuppressive TME could offer potential therapeutic opportunities. Indeed, these therapeutic approaches can be further revisited with the advent of nanotechnology that can target the key cellular components of TME and tumor cells more precisely. Synergetic targeting without eliciting systemic toxicity achieved by integration of antiangiogenic and immunotherapy in a single nanoplatform is vital for therapeutic success. In this review, we will discuss the most promising nanotechnological advancements oriented to modulate the immunosuppressive TME in association with antiangiogenic therapy that has gained immense popularity in cancer treatment. | Sadaf Hameed Pravin Bhattarai Zhifei Dai | 2018 | Science China(Life Sciences)2018，61，4： | 7 |
| 7 | Longest duration of retention of video capsule: A case report and literature review显示文摘Video capsule endoscopy (VCE) is a safe innovative tool for investigating obscure gastrointestinal bleeding, Crohn's disease and other small bowel pathologies. The capsule is usually excreted with faeces within 24-48 h. Retention of capsule rarely occurs, and it usually depends on the indication of VCE. The longest reported case of capsule retention in the literature is 2.5 years. Surgical approach is considered effective to retrieve the retained capsule. We present a case of asymptomatic retention of capsule for four and half years in a 49-year-old man who underwent VCE to explore the cause of obscure gastrointestinal bleeding. It was successfully retrieved endoscopically. We will also briefly review the literature regarding the causes, different presentations and management of capsule retention. | Mukul Bhattarai Pardeep Bansal Yakub Khan | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 7 |
| 8 | NaCl及生物降解活性剂对曝气灌溉水氧传输特性的影响显示文摘曝气灌溉可有效调节植物根区环境、改善土壤通气性。微咸水中NaCl的存在及活性剂添加对提高曝气灌溉的氧传质效率,实现节能高效的灌溉有重要作用。为研究NaCl介质及生物降解活性剂对纯氧曝气灌溉水氧传输特性的影响,该文采用变压分离制氧技术-氧气扩散系统-空气注射技术耦合系统,分析NaCl介质(未添加和添加)及生物降解活性剂BS1000(醇烷氧基化物质量浓度0、1、2、4 mg/L)2个因素对氧总传质系数、溶氧饱和度、流量均匀系数和溶氧均匀系数的影响。结果表明:BS1000的添加促进氧传质过程的发生,提高了曝气水中的溶氧饱和度;随着BS1000浓度增加,氧总传质系数逐渐增加,而溶氧饱和度呈现下降的趋势;BS1000质量浓度在2 mg/L及以上时,NaCl介质对氧总传质系数的增幅显著;NaCl介质对曝气水中的溶氧饱和度起到抑制作用。各组合条件下,曝气滴灌中流量均匀系数均在95%以上,溶氧均匀系数均在97%以上。添加活性剂BS1000可使氧总传质系数平均提高18.85%以上(P<0.05)。无论添加NaCl与否,添加1 mg/L BS1000的溶氧饱和度均最大,故1 mg/L BS1000是适宜的活性剂添加浓度。 | 雷宏军 刘欢 张振华 Bhattarai Surya Balsys Ron | 2017 | 农业工程学报2017，33，5： | 7 |
| 9 | Recent advances in chronic granulomatous disease显示文摘Chronic granulomatous disease(CGD)is an inherited defect of phagocyte function due to defective NADPH oxidase.Patients with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals and are prone to recurrent bacterial and fungal infections.Inflammatory complications are also noted in CGD such as colitis,non-infective granulomas causing gastrointestinal or urinary tract obstruction,hemophagocytic lymphohistiocytosis,and arthritis.Studies on toll-like receptor pathways and neutrophil extracellular traps in CGD have shed light on the role of NADPH oxidase in the innate immunity and pathogenesis of infections in CGD.Some reports also indicate a reduction of memory B cells and defective production of functional antibodies in CGD.Though the exact mechanisms for non-infective inflammatory complications in CGD are not yet clear,studies on efferocytosis and defective autophagy with inflammasome activation have made a substantial contribution to our understanding of the pathogenesis of inflammation in CGD.We also discuss the clinical and molecular features of p40phox defects and a newer genetic defect,EROS.Clinical phenotypes of X-linked carriers of CYBB are also discussed. | Gummadi Anjani Pandiarajan Vignesh Vibhu Joshi Jitendra Kumar Shandilya Dharmagat Bhattarai Jyoti Sharma Amit Rawat | 2020 | Genes & Diseases2020，7，1： | 6 |
| 10 | 不同增氧滴灌方式对蔬菜生长生理指标的影响显示文摘为了研究不同增氧方式对盆栽小白菜生长生理指标的影响,以小白菜为供试作物,采用盆栽地下滴灌的方式,以普通地下滴灌作为对照(CK),设置循环曝气(MAI)、过氧化氢(H 2O 2)、纯氧扩散器曝气(OC)及射流振荡器曝气(FO)4个增氧灌溉处理.结果表明,增氧地下滴灌显著提高了土壤呼吸速率,处理MAI,OC和FO较对照处理分别增大了65.87%,66.79%和111.62%.增氧地下滴灌促进了小白菜的根系生长、光合作用、蒸腾速率和气孔导度,进而提高了小白菜的物质量积累和产量.与对照相比,处理MAI的地下部鲜质量增大了42.03%,地下部干质量增大了79.85%;处理MAI,H 2O 2,OC和FO的光合速率分别增大了868.62%,794.14%,778.67%和650.19%;处理MAI,H 2O 2和OC的气孔导度较CK增大了157.14%,128.57%和85.71%,蒸腾速率增大了55.61%,32.38%和19.58%;处理MAI和H 2O 2的产量分别增大了56.36%和38.72%.综上,增氧地下滴灌可增强小白菜根区的土壤呼吸作用,改善光合作用、蒸腾速率和气孔导度,提高产量及水分利用效率.其中,循环曝气处理的改善效果最为显著. | 臧明 雷宏军 BHATTARAI Surya BALSYS Ron 徐建新 | 2020 | 排灌机械工程学报2020，38，3： | 4 |
| 11 | Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level显示文摘Alzheimer’s disease cannot be cured as of yet.Our current understanding on the causes of Alzheimer’s disease is limited.To develop treatments,experimental models that represent a particular cellular phase of the disease and more rigorous scrutiny of the cellular pathological mechanisms are crucial.In recent years,Alzheimer’s disease research underwent a paradigm shift.According to this tendency,Alzheimer’s disease is increasingly being conceived of a disease where not only neurons but also multiple cell types synchronously partake to manifest the pathology.Knowledge on every cell type adds an alternative approach and hope for the efforts towards the treatment.Neural stem cells and their neurogenic ability are making an appearance as a new aspect of the disease manifestation based on the recent findings that neurogenesis reduces dramatically in Alzheimer’s disease patients compared to healthy individuals.Therefore,understanding how neural stem cells can form new neurons in Alzheimer’s disease brains holds an immense potential for clinics.However,this provocative idea requires further evidence and tools for investigation.Recently,single cell sequencing appeared as a revolutionary tool to understand cellular programs in unprecedented resolution and it will undoubtedly facilitate comprehensive investigation of different cell types in Alzheimer’s disease.In this mini-review,we will touch upon recent studies that use single cell sequencing for investigating cellular response in Alzheimer’s disease and some consideration pertaining to the utilization of neural regeneration for Alzheimer’s disease research. | Mehmet Ilyas Cosacak Prabesh Bhattarai Caghan Kizil | 2020 | Neural Regeneration Research2020，15，5： | 4 |
| 12 | Biodiversity and Invasibility: Distribution Patterns of Invasive Plant Species in the Himalayas, Nepal显示文摘Invasive plant species are exerting a serious threat to biological diversity in many regions of the world. To understand plant invasions this study aims to test which of the two plant invasiveness hypotheses; ‘low native diversity' vs. ‘high native diversity', is supported by the regional distribution patterns of invasive plant species in the Himalayas,Nepal. This study is based on data retrieved from published literatures and herbarium specimens. The relationship between invasive plant species distribution patterns and that of native plant species is elucidated by scatter plots, as well as by generalized linear models. The native plant species and invasive plant species have similar distribution patterns and the maximum number of invasive plant species is found in the same altitudinal range where the highest richness for native tree species is found. There is a clear trend of higher invasive plant richness in regions where native tree species richness is relatively high.Consequently, the native plant richness is highest in the central phytogeographic region, followed by the eastern and the western regions, respectively. The invasive plant species also follows a similar trend.Additionally, the invasive plant species richness was positively correlated with anthropogenic factors such as human population density and the number of visiting tourists. This study supports the hypothesis that ‘high native diversity' supports or facilitates invasive plant species. Further, it indicates that nativeand invasive plant species may require similar natural conditions, but that the invasive plant species seem more dependent and influenced by anthropogenic disturbance factors. | BHATTARAI Khem Raj M?REN Inger Elisabeth SUBEDI Suresh Chandra | 2014 | Journal of Mountain Science2014，11，3： | 4 |
| 13 | 气源及活性剂对曝气滴灌带水气单双向传输均匀性的影响显示文摘曝气滴灌过程中水、氧、气传输均匀性是评价曝气灌溉质量的重要指标。活性剂的添加和传输方式的优选对曝气滴灌传输过程中微气泡的存在和溶解氧的保持有重要意义。为提高水气耦合物在滴灌过程中传输的距离和均匀性,该文采用Mazzei 1078文丘里空气射流器进行曝气增氧,以空气和氧气为供试气源,研究活性剂BS1000浓度(0、1、2和4 mg/L)和传输方式(单向和双向)对曝气滴灌下水、氧、气传输特性的影响。结果表明:曝气导致单向传输下流量均匀性略有下降,但可显著提高灌溉水中溶解氧和掺气比例;随着活性剂浓度的增加,掺气比例显著增加(P<0.05);活性剂的添加促进了氧气曝气下溶解氧的增加;溶氧均匀性和流量均匀性随着活性剂浓度的增加无显著性变化,但单向传输下4 mg/L BS1000的出气均匀性较未添加活性剂显著降低;双向传输的流量均匀性、溶氧均匀性和出气均匀性分别在95%、96%和67%以上,较单向传输分别平均提高14.00%、4.05%和30.64%(P<0.05),是曝气滴灌长程管道传输推荐的布置方式。研究结果为曝气滴灌过程中灌溉技术参数优化和管道的科学布置提供理论依据。 | 雷宏军 刘欢 Bhattarai Surya Balsys Ron 潘红卫 | 2018 | 农业工程学报2018，34，19： | 4 |
| 14 | Differential response of tomato genotypes to Xanthomonas-specific pathogen-associated molecular patterns and correlation with bacterial spot (Xanthomonas perforans) resistance显示文摘Plants depend on innate immune responses to retard the initial spread of pathogens entering through stomata,hydathodes or injuries.These responses are triggered by conserved patterns in pathogen-encoded molecules known as pathogen-associated molecular patterns(PAMPs).Production of reactive oxygen species(ROS)is one of the first responses,and the resulting‘oxidative burst’is considered to be a first line of defense.In this study,we conducted association analyses between ROS production and bacterial spot(BS;Xanthomonas spp.)resistance in 63 genotypes of tomato(Solanum lycopersicum L.).A luminol-based assay was performed on leaf tissues that had been treated with a flagellin 22(flg22),flagellin 28 and a Xanthomonas-specific flg22(flg22-Xac)peptide,to measure PAMP-induced ROS production in each genotype.These genotypes were also assessed for BS disease response by inoculation with Xanthomonas perforans,race T4.Although there was no consistent relationship between peptides used and host response to the BS,there was a significant negative correlation(r=−0.25,P<0.05)between foliar disease severity and ROS production,when flg22-Xac was used.This response could potentially be used to identify the Xanthomonas-specific PRR allele in tomato,and eventually PAMP-triggered immunity loci could be mapped in a segregating population.This has potential significance in tomato improvement. | Krishna Bhattarai Frank J Louws John D Williamson Dilip R Panthee | 2016 | Horticulture Research2016，3，1： | 3 |
| 15 | δ^(15)N-stable isotope analysis of NH_(x): An overview on analytical measurements, source sampling and its source apportionment显示文摘Agricultural sources and non-agricultural emissions contribute to gaseous ammonia(NH_(3))that plays a vital role in severe haze formation.Qualitative and quantitative contributions of these sources to ambient PM_(2.5)(particulate matter with an aerodynamic equivalent diameter below 2.5µm)concentrations remains uncertain.Stable nitrogen isotopic composition(δ^(15)N)of NH_(3)and NH_(4)+(δ^(15)N(NH_(3))andδ^(15)N(NH_(4)+),respectively)can yield valuable information about its sources and associated processes.This review provides an overview of the recent progress in analytical techniques forδ^(15)N(NH_(3))andδ^(15)N(NH_(4)+)measurement,sampling of atmospheric NH_(3)and NH_(4)+in the ambient air and their sources signature(e.g.,agricultural vs.fossil fuel),and isotope-based source apportionment of NH_(3)in urban atmosphere.This study highlights that collecting sample that are fully representative of emission sources remains a challenge in fingerprintingδ^(15)N(NH_(3))values of NH_(3)emission sources.Furthermore,isotopic fractionation during NH_(3)gas-to-particle conversion under varying ambient field conditions(e.g.,relative humidity,particle pH,temperature)remains unclear,which indicates more field and laboratory studies to validate theoretically predicted isotopic fractionation are required.Thus,this study concludes that lack of refinedδ^(15)N(NH_(3))fingerprints and full understanding of isotopic fractionation during aerosol formation in a laboratory and field conditions is a limitation for isotope-based source apportionment of NH_(3).More experimental work(in chamber studies)and theoretical estimations in combinations of field verification are necessary in characterizing isotopic fractionation under various environmental and atmospheric neutralization conditions,which would help to better interpret isotopic data and our understanding on NH_(x)(NH_(3)+NH_(4)+)dynamics in the atmosphere. | Noshan Bhattarai Shuxiao Wang Yuepeng Pan Qingcheng Xu Yanlin Zhang Yunhua Chang Yunting Fang | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 3 |
| 16 | Distribution Pattern of Vascular Plant Species of Mountains in Nepal and their Fate Against Global Warming显示文摘This study aims to find the altitudinal distribution pattern of vascular plant species reported from high mountain of Nepal(Manang) along the whole Himalayan elevation gradient, and evaluate their fate against climate change. Data was gathered from multiple sources, field investigations, literatures, and herbarium specimens. Altogether, 303 vascular plant species were reported from Manang. We used a published data to calculate distribution range of each species by interpolating between its upper and lower elevation limits. The relationship between elevation and species richness is elucidated by generalized linear model. The consequence of global warming upon Manang's vascular plant species was estimated based on projected temperature change for next century and adiabatic lapse rate along the elevation gradient of the Himalayas. The vascular plant species richness has a unimodel relationship with elevation along the whole elevation gradient of Nepal as well as in three biogeographical regions of Nepal. Vascular plants of Manang are found distributed from low land Terai to high alpine regions of Nepal and their elevation distribution range varies from 200 to 4700 m. Out of 303 vascular plants of Manang, only seven species might be affected if temperature increase by 1.5°C, whereas at least 70 species will be affected with 5°C temperature increased. However, the majority of species(233 species) have wider distribution range(> 1000 m) and more than 5°C temperature tolerance range, thus they are likely to be less affected from global warming by the end of 21 st century. | Suresh Chandra SUBEDI Khem Raj BHATTARAI Ram Prasad CHAUUDHARY | 2015 | Journal of Mountain Science2015，12，6： | 3 |
| 17 | Factors determining the side of approach for clipping ruptured anterior communicating artery aneurysm via supraorbital eyebrow keyhole approach显示文摘Purpose:The purpose of this study was to review the microsurgical anatomy and clipping of ruptured anterior communicating artery(AComA)aneurysms and to plan and avoid complications before operation.Methods:A total of 523 cases of cerebral aneurysms admitted to the neurosurgery department of the Third Affiliated Hospital of Sun Yat-Sen University from September 2010 to October 2018 were analyzed retrospectively.Among them,85 patients had ruptured AComA aneurysms.This study was limited to 85 of these cases,whose satisfactory preoperative angiographic diagnostic films can be retrieved from the hospital database system because of the need for detailed review.Results:We performed supraorbital eyebrow keyhole approach(SOEK)craniotomy in 85 patients to clip 85 AComA aneurysms,in the setting of subarachnoid hemorrhage(SAH).Patients’mean age was(52.69±9.94)years(range,28e78 years).The proportions of small,medium and large aneurysms were 83.5%,15.3%,and 1.2%,respectively.The average size of the aneurysms was(5.07±2.36)mm.There were 77.8% of patients with inferior aneurysms and 81.3% of patients with superior aneurysms achieved good results.There was a significant correlation between A1 dominance and operation method(p<0.001).There was no significant relationship between surgical approach and aneurysm projection or A2 plane(p=0.157&p=0.318).Conclusion:Regardless of whether the A2 plane is open or closed,the A1 dominant side is still a better choice for accessing AComA aneurysms to avoid dangerous premature bleeding. | Robin Bhattarai Chao-Feng Liang Chuan Chen Hui Wang Teng-Chao Huang Ying Guo | 2020 | Chinese Journal of Traumatology2020，23，1： | 3 |
| 18 | Role of bromocriptine in multi-spectral manifestations of traumatic brain injury显示文摘PurposeDespite 创伤的大脑损害的流行和费用联系了残疾,在 pharmacotherapy 的现代途径上的文学有少量。药可以由没有影响其它,提高一些神经病学的功能支持恢复。此处,我们与创伤的大脑 injury.MethodsA 队处于最低限度地有意识的状态包括创伤的大脑损害的 36 个选择 nonsurgical 盒子为病人在 neurorehabilitation 讨论了 bromocriptine 的角色在学习被注册。在血液动力学的稳定性以后, bromocriptine 在 3.75 mg/d 的儿科学的剂量和 7.5 mg/d 的成年剂量被给。它被管理通过一 naso 胃(NG ) 用最低限度地有意识的状态在病人喂试管,然后在合适的吞咽以后改变了到口头的线路并且好作呕反射在病人被保证。这药超过三个星期慢慢地在病人在神经病学的改进以后被减少。积极结果被至少 1 个英国医药委员会(BMC ) 马达分数被 2 的改进 GCS 分数和马达功率决定。赤字的改进为失语症,切换的任务,为认知和注意的两倍 tasking 和做小道的测试,和功能的独立措施为马达工作获得的位跨度和 self-independence.ResultsAccelerated 唤起以讲话的流利被评估在 4-40 天内在 47.0% 盒子(8/17 ) 中被看见。在 41.2% 盒子(7/17 ) 中,格拉斯哥结果分数(去) 在 90 天内被改进到 4/5。在在至少 1 个 BMC 分数的 hemiparesis 的改进在 40 天内在 55.6% 盒子(5/9 ) 中被看见。失语症在 7-30 天内在 80% 盒子(4/5 ) 中被改进。在认知缺陷的中等改进在 14-20 天内在 66.7% 盒子(2/3 ) 中被看见。在记忆的改进在超过 30 天内在 50% 盒子(1/2 ) 中被观察。因为这药的不利反应,没有盒子从学习被撤退。在学习 group.ConclusionBromocriptine 没有死亡在病人改进创伤的大脑损害以及全面结果的神经病学的 sequelae。如果药被给支持恢复并且对待它的联系残疾,临床医生们应该彻底地构画出目标并且仔细监视不利效果。 | Sunil Munakomi Binod Bhattarai Bijoy Mohan Kumar | 2017 | Chinese Journal of Traumatology2017，20，2： | 2 |
| 19 | Magnesium incorporated chitosan based scaffolds for tissue engineering applications显示文摘Chitosan based porous scaffolds are of great interest in biomedical applications especially in tissue engineering because of their excellent biocompatibility in vivo,controllable degradation rate and tailorable mechanical properties.This paper presents a study of the fabrication and characterization of bioactive scaffolds made of chitosan(CS),carboxymethyl chitosan(CMC)and magnesium gluconate(MgG).Scaffolds were fabricated by subsequent freezing-induced phase separation and lyophilization of polyelectrolyte complexes of CS,CMC and MgG.The scaffolds possess uniform porosity with highly interconnected pores of 50-250 μm size range.Compressive strengths up to 400 kPa,and elastic moduli up to 5 MPa were obtained.The scaffolds were found to remain intact,retaining their original threedimensional frameworks while testing in in-vitro conditions.These scaffolds exhibited no cytotoxicity to 3T3 fibroblast and osteoblast cells.These observations demonstrate the efficacy of this new approach to preparing scaffold materials suitable for tissue engineering applications. | Udhab Adhikari Nava PRijal Shalil Khanal Devdas Pai Jagannathan Sankar Narayan Bhattarai | 2016 | Bioactive Materials2016，1，2： | 2 |
| 20 | PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release显示文摘 | Narayan Bhattarai Hassna R. Ramay Jonathan Gunn Frederick A. Matsen Miqin Zhang | 2005 | Journal of Controlled Release2005，，3： | 2 |
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