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| 1 | 电休克治疗用于精神分裂症的激越症状:随机对照试验的meta分析(英文)显示文摘背景:躁动在精神分裂症治疗中是一个重大挑战。电休克疗法(ECT)对各种精神疾病是一种快速、有效、和安全的治疗,但ECT对精神分裂症的躁动治疗的相关meta分析还尚未报道。目标:系统地评估单一使用ECT或ECT合并使用其他抗精神病药物(APs)的对精神分裂症的躁动治疗的有效性和安全性。方法:进行随机对照试验(RCT)的系统文献搜索。两名独立评估者筛选研究、提取结果数据与现有数据的安全性、进行质量评估和数据合成。采用建议、评估、开发、和评价的工作组等级(GRADE)来判断主要成果的证据的总体水平。结果:一共确定了中国有七个RCTs,包括ECT单一使用(4个RCTs有5个治疗组,n=240)和ECT-APs合并使用(3个RCTs,n=240)。研究对象平均年龄34.3(4.5)岁,平均治疗时间为4.3(3.1)周。所有7个RCTs非盲法,并且根据Jadad量表7项RCTs均被评为低质量。样本的Meta分析发现与APs单一治疗相比,单一使用ECT或ECT-APs合并使用阳性和阴性症状量表(PANSS)的躁动子因子评分改善均无显著性差异(ECT单一使用:weighted mean difference(WMD)=-0.90,95%confidence interval(CI):(-2.91,1.11),p=0.38;ECT-APs合并使用:WMD=-1.34,(95%CI:-4.07,1.39),p=0.33)。然而,PANSS总分(WMD=-7.13,I^2=0%,p=0.004)和兴奋子因子评分(WMD=-1.97,p<0.0001)、ECT治疗14天后的PANSS总分(WMD=-7.13,I^2=0%,p=0.004)和第7天和第14天的兴奋子因子评分(WMD=-1.97to-1.92,p=0.002 to 0.0001)均显示单一使用ECT优于APs单一治疗。ECT-APs合并治疗结束时(WMD=-10.40,p=0.03)和治疗后7天(WMD=-5.01,p=0.02)的PANSS总分显示均优于APs单药治疗。头痛(p=0.0001,number-needed-to-harm(NNH)=3,95%CI=2-4)是唯一的ECT单一治疗后不良反应,并且ECT单一治疗组比APs单药治疗发生的更频繁。根据GRADE方法,主要结果的证据水平被评为'非常低'(37.5%)和'低'(50%)。结论:基于中国7个RCTs合并的数据发现ECT单一治疗或ECT-APs合并治疗在精神分裂症患者的躁动治疗中并没有优势。然而,ECT单一治疗或ECT-APs合并治疗均与PANSS总分减低显著有关。需要高质量的RCTs验证目前的解释。 | 顾小静 郑伟 郭彤 Gabor S.Ungvari Helen F.K.CHiu 操小兰 CarlD'Arcy 孟祥飞 宁玉萍 项玉涛 | 2017 | 上海精神医学2017，29，1： | 6 |
| 2 | Free electron lasers driven by plasma accelerators:status and near-term prospects显示文摘Owing to their ultra-high accelerating gradients,combined with injection inside micrometer-scale accelerating wakefield buckets,plasma-based accelerators hold great potential to drive a new generation of free-electron lasers(FELs).Indeed,the first demonstration of plasma-driven FEL gain was reported recently,representing a major milestone for the field.Several groups around the world are pursuing these novel light sources,with methodology varying in the use of wakefield driver(laser-driven or beam-driven),plasma structure,phase-space manipulation,beamline design,and undulator technology,among others.This paper presents our best attempt to provide a comprehensive overview of the global community efforts towards plasma-based FEL research and development. | C.Emma J.Van Tilborg R.Assmann S.Barber A.Cianchi S.Corde M.E.Couprie R.D'Arcy M.Ferrario A.F.Habib B.Hidding M.J.Hogan C.B.Schroeder A.Marinelli M.Labat R.Li J.Liu A.Loulergue J.Osterhoff A.R.Maier B.W.J.Mc Neil W.Wang | 2021 | High Power Laser Science and Engineering2021，9，4： | 2 |
| 3 | 幻肢痛的处置显示文摘问:病人2d前行右膝下截肢术,现诉右踝部(已截除)间歇性烧灼痛。这是幻肢痛,治疗上有什么办法呢?
答:幻肢痛为神经痛的一种类型。截肢后约60%。80%病人有间歇性幻肢痛或无痛的肢体幻觉。特点为间歇性出现的烧灼感、跳痛、刺痛或挤压痛。在术后早期出现较为常见且严重,但在数月后的康复期间歇性出现。 | D'Arcy Y 高丽梅(摘) 李彦(校) | 2007 | 国际护理学杂志2007，26，7： | 2 |
| 4 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase 显示文摘 | Thoma R Schulz-Gasch T D'Arcy B | 2004 | Nature2004，432，7013： | 1 |
| 5 | Comparison of free-breathing with navigator-controlled acquisition regimes in abdominal diffusion-weighted magnetic resonance images: effect on ADC and IVIM statistics显示文摘 | Jerome N P Orton M R D'Arcy J A | 2014 | J Magn Reson Imaging2014，39，1： | 1 |
| 6 | Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis显示文摘 | Docquier F Farrar D D'Arcy V | 2005 | Cancer Res2005，65，12： | 1 |
| 7 | Volatile sulphur compounds in UHT milk显示文摘 | Al-Ayyabi Z D’Arcy B R Deeth H C | 2009 | Critical Reviews in Food Science and Nutrition2009，49，： | 1 |
| 8 | Lactation mastitis:occurrence and medical management among 946 breastfeeding women in the United States显示文摘 | Foxman B D'Arcy H Gillespie B | 2002 | Am J Epidemiol2002，155，2： | 1 |
| 9 | Treatment of fractures of the femoral neck by replacement with Thompson prosthesis 显示文摘 | D'arcy J Devas M | 1976 | J Bone Joint Surg1976，58，3： | 1 |
| 10 | Computationally efficient vascular input function models for quantitative kinetic modelling using DCE-MRI 显示文摘 | Orton MR d'Arcy JA Walker-Samuel S | 2008 | Phys Med Biol2008，53，： | 1 |
| 11 | Structure of human pancreatic lipase 显示文摘 | Winkler F K D'Arcy A Hunziker W | 1990 | Nature1990，343，： | 1 |
| 12 | Factors associated with weaning in the first 3 months postpartum显示文摘 | Schwartz K D' Arcy HJ Gillespie B | 2002 | J Fam Pract2002，51，5： | 1 |
| 13 | A comparison of property/casuahy insurance financial pricing models 显示文摘 | D'Arcy S P Gorvett R W | 1998 | Pro- ceedings of the Casualty Actuarial Society1998，，162： | 1 |
| 14 | Electrophysiological assessment of language function following stroke 显示文摘 | D' Arcy RN Marchand Y Eskes GA | 2003 | Clin Neurophysiol2003，114，4： | 1 |
| 15 | Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus 显示文摘 | D'ARCY D M LIU B Corrigan 0 I | 2011 | lnt J Pharm2011，419，12： | 1 |
| 16 | Comparison offree-breathing with navigator-controlled acquisition regimesin abdominal diffusion-weighted magnetic resonance images:Effect on ADC and IVIM statistics显示文摘 | Jerome NP Orton MR d'Arcy JA | 2014 | J Magn Reson Imaging2014，39，1： | 1 |
| 17 | In situ localization of barley yellow dwarf virus coat protein in oats显示文摘 | Nass P H Jakstys B P D'Arcy C J | 1995 | Phytopathology1995，85，： | 1 |
| 18 | Flavour retention during high temperature short time extrusion cooking process: a review显示文摘 | BHANDARI B D'ARCY B YOUNG G | 2001 | International Journal of Food Science and Technology2001，36，： | 1 |
| 19 | Structure of Human Neutral Endopeptidase(Neprilysin)Complexed with Phosphoramidon显示文摘 | D'Arcy A HennigM | 2000 | J Mol Biol2000，296，2： | 1 |
| 20 | Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon显示文摘 | Oefner C D'Arcy A Hennig M | 2000 | J Mol Biol2000，296，2： | 1 |
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