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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | One-step Crystallization Kinetic Parameters of the Glass-ceramics Prepared from Stainless Steel Slag and Pickling Sludge显示文摘One-step crystallization is one of the most energy conserving methods for glass-ceramics preparation.However,only a few kinetics studies focused on the glass-ceramics prepared by the one-step crystallization.The onestep crystallization kinetic parameters were studied using differential scanning calorimetry.The activation energy(Ea)and the Avrami parameter(n)were calculated as 152.79kJ·mol-1 and 4.39,respectively.These parameters indicate that continuous nucleation and three-dimensional crystal growth are the dominating mechanisms in the one-step crystallization process of the parent glass.The properties of the obtained glass-ceramics can be compared to the glass-ceramics prepared by the two-stage heat treatment and sintering method.This crystallization kinetics research can be used to evaluate the one-step crystallization potential of a parent glass. | Shen-gen ZHANG Jian YANG Bo LIU De-an PAN Chun-li WU Alex A.VOLINSKY | 2016 | Journal of Iron and Steel Research(International)2016，23，3： | 7 |
| 3 | Treatment method of hazardous pickling sludge by reusing as glass–ceramics nucleation agent显示文摘Heavy metal containing pickling sludge(PS) is one of the by-products of the stainless-steel-making industry,which has been considered hazardous due to contained chromium and nickel.Traditional methods of PS disposing are landfill and cement solidification.This research is aimed at disposing PS by solidification/stabilization and reusing it as a nucleation agent of glass–ceramics.The crystallization behavior and the properties of a glass in the CaO–MgO–SiO_2–Al_2O_3 system were studied by considering PS as the nucleation agent.Experimental results confirm that introducing 14 wt% PS as the nucleation agent of glass–ceramics can decrease crystallization temperature by 110.8 °C,refine the grain size by forming isometric crystals with size of 2 lm,enhance Vickers hardness by 2690 MPa and decrease water absorption from(1.21 ± 0.10) wt% to(0.04 ± 0.01) wt%.Therefore,it is reasonable to conclude that PS can be utilized as a nucleation agent to improve the crystallization and mechanical properties of the glass–ceramics.The testing results of US EPA toxicity characteristic leaching procedure(TCLP)confirm the safety of this reusing method. | Jian Yang Shen-Gen Zhang De-An Pan Bo Liu Chun-Li Wu Alex A.Volinsky | 2016 | Rare Metals2016，35，3： | 6 |
| 4 | Glycolysis in the control of blood glucose homeostasis显示文摘Glycolysis,a simple pathway of glucose metabolism,critically regulates insulin secretion and metabolic functions of various cells.Depending on cell types,rates of glycolysis are determined at various steps of glycolysis that are subjected to the control of key metabolic and regulatory enzyme(S),which include glucokinase,6-phosphofructo-I-kinase,and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.These enzymes are regulated by both nutritional and hormonal signals at the levels of transcription,translation,and post-translational modifications.In hepatocytes,glycolysis is involved in the control of hepatic glucose production.The latter,when excessive,contributes to hyperglycemia in diabetes.In pancreatic β cells,glycolysis couples glucose-stimulated insulin secretion.Absolute or relatively low levels of circulating insulin causes hyperglycemia.In adipocytes,glycolysis generates metabolites for lipogenesis and channels fatty acids from excessive oxidation to triglyceride synthesis,thereby reducing oxidative stress.With increased proinflammatory status,adipocytes produce pro-hyperglycemic factors and bring about hyperglycemia and insulin resistance.In hypotha lamic neurons,glycolysis conveys nutrient sensing that is related to feeding control.Dysregulation of glycolysis occurs in conditions of insulin deficiency or resistance,and is attributable to inappropriate amount and/or activities of metabolic and regulatory enzymes of glycolysis.Targeting key metabolic and regulatory enzymes to enhance glycolysis may offer viable approaches for treatment of diabetes. | Xin Guo Honggui Li Hang Xu Shihlung Woo Hui Dong Fuer Lu Alex J.Lange Chaodong Wu | 2012 | Acta Pharmaceutica Sinica B2012，2，4： | 3 |
| 5 | Penile prosthesis implantation in Chinese patients wit severe erectile dysfunction: 10-year experience显示文摘我们回顾地与严重可勃起的机能障碍(SED ) 在中国病人评估了阴茎修复术培植(PPI ) 的临床的结果。从 2000 年 7 月到 2011 年 12 月, 224 个病人(吝啬的年龄:35.9 ± 11.8 年,变化:20-75 年) 在我们的中心根据标准 PPI 过程由富有经验的外科医生与 SED 经历了 PPI。韧性的修复术(AMS 650 ) 在 45 种情况中被植入(20.1 %) ,并且三片的可膨胀的修复术(AMS 700 CXM 或 AMS 700 CXR ) 在 179 种情况中被植入(79.9 %) 。包括手术后的复杂并发症,临床的功效和夫妇满足,外科的结果被评估在上比手术后地使用医药记录抽象的 6 个月, IIEF-5,生活(QoL ) 的质量分数,和病人 / 搭挡的性满足分数由 Bhojwani 等求婚了。为学习合格的 224 个病人, 201 使遭到(89.7 %) 完成的后续。所有能与吝啬的手术后的 IIEF-5 病人执行性交柱子 PPI, QoL 分数是 20.02 ± 2.32 和 5.28 ± 0.76,分别地它显著地与外科手术前的分数相比被改进(6.29 ± 1.5 和 2.13 ± 0.84, P< 0.01 ) 。201 个人,机械失灵发生在四种情况中(2.0 %) 并且三个盒子被重新植入新设备,和二个盒子(1.0 %) 开发了阴茎的温和弯曲。有感染的阴囊的侵蚀与糖尿病 mellitus 发生在一种情况中(0.5 %) 并且植入的 AMS 的要求的完全的移动 700 CXM。令人满意的性交被 178 个人两次至少每月报导(88.6 %) ,并且对 PPI 外科的全面满足被 89.0 % 报导;人和 82.5 %搭挡。在三片的可膨胀的修复术组的耐心的满足比在韧性的修复术组高(P< 0.05 ) 。然而,在 prostheses 的类型之间,满足没在搭挡调查不同。PPI 是一种安全、有效的治疗选择因为有 SED 和富有经验的外科医生的中国病人根据标准 PPI 执行 PPI 过程能减少 PPI 的手术后的复杂并发症并且能改进耐心的满足比率和 QoL。 | Wei-Dong Song Yi-Ming Yuan Wan-Shou Cui Alex K Wu Yi-Chen Zhu Jing Liu Lin Wang Guang-Yi Ba Jing Peng Zhi-Chao Zhang Bing Gao Ying-Lu Guo Tom F Lue Zhong-Cheng Xin | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 6 | Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification显示文摘LaPeyronie 的疾病(PD ) 的 pathophysiology 被认为是 multifactorial,包含愈合的基因倾向,损伤,发炎和改变的创伤。然而,这些因素还没用动物模型被验证了。在这研究,我们介绍了 tunica albuginea allograft 获得的一个新模型。40 的一个总数, 16-week-old 男性老鼠被使用。这些, 8 只老鼠用作控制并且经历了 10 ×有随后的 autografting 的 2-mm-wide tunical 切除,而留下 32 与另一只老鼠的 tunica 与缺点的 grafting 经历了一样的切除。词法、功能测试在 grafting 以后在 1, 3, 7 和 12 个星期被执行。Intracavernous 压力,阴茎弯曲的度和有弹性的纤维长度为在 allograft 和控制组之间的比较被评估。纸巾为组织学的检查被获得。阴茎弯曲作为与控制老鼠相比在 allografted 老鼠是显著地更大的。可勃起的功能在所有老鼠被维持,除了在在 12 个星期估计的那些。弹力素纤维长度作为与控制相比在 allografted tunica 被减少。SMAD2 表示在 allograft 的内部部分被检测,并且 collagen-II- 和 osteocalcin 积极的房间也被注意。在老鼠的 Tunica albuginea (TA ) allograft 是 PD 的一个优秀模型。在 12 个星期和在 TA 的内部层的骨化的存在以后的弯曲的坚持类似于与 PD 在人观察的那些。用这个动物模型的确认研究将为有效治疗学的干预帮助 PD pathophysiology 的理解。 | Ludovic Ferretti Thomas M Fandel Xuefeng Qiu Haiyang Zhang Hazem Orabi Alex K Wu Lia Banie Guifang Wang Guiting Lin Ching-Shwun Lin Tom FLue | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 7 | Enhancing IoT anomaly detection performance for federated learning显示文摘Federated Learning (FL) with mobile computing and the Internet of Things (IoT) is an effective cooperative learning approach. However, several technical challenges still need to be addressed. For instance, dividing the training process among several devices may impact the performance of Machine Learning (ML) algorithms, often significantly degrading prediction accuracy compared to centralized learning. One of the primary reasons for such performance degradation is that each device can access only a small fraction of data (that it generates), which limits the efficacy of the local ML model constructed on that device. The performance degradation could be exacerbated when the participating devices produce different classes of events, which is known as the class balance problem. Moreover, if the participating devices are of different types, each device may never observe the same types of events, which leads to the device heterogeneity problem. In this study, we investigate how data augmentation can be applied to address these challenges and improving detection performance in an anomaly detection task using IoT datasets. Our extensive experimental results with three publicly accessible IoT datasets show the performance improvement of up to 22.9% with the approach of data augmentation, compared to the baseline (without relying on data augmentation). In particular, stratified random sampling and uniform random sampling show the best improvement in detection performance with only a modest increase in computation time, whereas the data augmentation scheme using Generative Adversarial Networks is the most time-consuming with limited performance benefits. | Brett Weinger Jinoh Kim Alex Sim Makiya Nakashima Nour Moustafa K.John Wu | 2022 | Digital Communications and Networks2022，8，3： | 2 |
| 8 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 9 | Agrobacterium-mediated stable transformation of cell suspension cultures of barley (Hordeum vulgare)显示文摘 | Huixia Wu Alex C. McCormac Malcolm C. Elliott Dong-Fang Chen | 1998 | Plant Cell Tissue and Organ Culture1998，，3： | 1 |
| 10 | Sensitivity of ozone to precursor emissions in urban Beijing with a Monte Carlo scheme显示文摘 | Xiao Tang Zifa Wang Jiang Zhu Alex E. Gbaguidi Qizhong Wu Jie Li Tong Zhu | 2010 | Atmospheric Environment2010，，31： | 1 |
| 11 | Fault current limiter applications in medium and high-voltage power distribution systems 显示文摘 | Alex Y Wu Yuexin Yin | 1998 | IEEE Transactions on Industrial Applications1998，34，1： | 1 |
| 12 | Room temperature ionic liquids as replacements for conventional solvents – A review显示文摘 | Kenneth N. Marsh Alex Deev Alex C-T. Wu Emma Tran A. Klamt | 2002 | Korean Journal of Chemical Engineering2002，，3： | 1 |
| 13 | 显示文摘 | Chen X Wu N J Alex Ignatiev | 1999 | Thin Solid Films1999，350，12： | 1 |
| 14 | Multi-level data hiding for digital image and video显示文摘 | Min Wu Hong Heather Yu Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
| 15 | Correlation Between Serum Prostate Specific Antigen and Prostate Volume in Taiwanese Men With Biopsy Proven Benign Prostatic Hyperplasia显示文摘 | Yu-Lung Chang Alex T.L. Lin Kuang-Kuo Chen Yen-Hwa Chang Howard H.H. Wu Junne-Yih Kuo William J.S. Huang Shing-Hwa Lu Yen-Shen Hsu Hsiao-Jen Chung Shyh-Chyi Chang | 2006 | The Journal of Urology2006，，1： | 1 |
| 16 | Multi-level data hiding for digital image and video显示文摘 | WU Min HONG Heather YU Alex Gelman | 2007 | IEEE Transactions on Image Processing2007，23，6： | 1 |
| 17 | Factors affecting mem-bers' trust belief and behaviour intention in virtualcommunities 显示文摘 | Wu Jyh-Jeng Tsang Alex S L | 2008 | Behaviour & Information Technolo-gy2008，27，2： | 1 |
| 18 | Beyond fundamental resonance mode:high-order multi-band ALN PMUT for in vivo photoacoustic imaging显示文摘This paper reports on an aluminum nitride(AlN)piezoelectric micromachined ultrasound transducer(PMUT)array for photoacoustic(PA)imaging,where the high-order resonance modes of the PMUT are utilized to improve imaging resolution.A flexural vibration mode(FVM)PMUT is fabricated and applied in a photoacoustic imaging(PAI)system.Specifically,the microelectromechanical system(MEMS)-based PMUT is suitable for PA endoscopic imaging of blood vessels and bronchi due to its miniature size and high sensitivity.More importantly,AlN is a nontoxic material,which makes it harmless for biomedical applications.In the PAI system,the AlN PMUT array is used to detect PA signals,and the acousto–mechanical response is designed and optimized at the PMUT’s fundamental resonance.In this work,we focus on the high-order resonance performance of the PMUT PAI beyond the fundamental resonance.The acoustic and electrical responses of the PMUT’s high-order resonance modes are characterized and analyzed.The fundamental and three high-order resonance bandwidths are 2.2,8.8,18.5,and 48.2 kHz.Compared with the resolution at the fundamental resonance mode,the resolutions at third-and fourth-order resonance modes increase by 38.7%and 76.9%in a phantom experiment.The high-order resonance modes of the AlN PMUT sensor array provide higher central frequency and wider bandwidth for PA signal detection,which increase the resolution of PAI compared to the PMUT working at the fundamental resonance mode. | Junxiang Cai Yiyun Wang Daohuai Jiang Songsong Zhang Yuandong Alex Gu Liang Lou Fei Gao Tao Wu | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 19 | A low-harmonic electric drive system based on current-source inverter 显示文摘 | Yin Yuexin Wu Alex Y | 1998 | IEEE Transactions on Industrial Applications1998，34，1： | 1 |
| 20 | Single-port-access (SPATM) cholecystectomy: a multi-institutional report of the first 297 cases显示文摘 | Paul G. Curcillo Andrew S. Wu Erica R. Podolsky Casey Graybeal Namir Katkhouda Alex Saenz Robert Dunham Steven Fendley Marc Neff Chad Copper Marc Bessler Andrew A. Gumbs Michael Norton Antonio Iannelli Rodney Mason Ashkan Moazzez Larry Cohen Angela Mouhla | 2010 | Surgical Endoscopy2010，，8： | 1 |
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