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| 1 | Role of vitamins in gastrointestinal diseases显示文摘A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases.For instance,most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive role.On the other hand,more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities.Examples for this include the therapeutic role of vitamin E in patients with nonalcoholic steatohepatitis,the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitamin C in reducing the risk of gallstones,the positive outcome with vitamin B12 in patients with aphthous stomatitis,and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease.Other potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential fields.Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years.Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost,their use should be encouraged in the fields where positive data are available. | Omar A Masri Jean M Chalhoub Ala I Sharara | 2015 | World Journal of Gastroenterology2015，21，17： | 8 |
| 2 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 3 | Cystatin C as a marker for glomerular filtration rate in pediatric patients显示文摘 | Ylinen ES Ala Houhala M Harmoinen AP | 2004 | Pediatr Nephrol2004，13，6： | 1 |
| 4 | Antifreeze protein produced endogenously in winter rye leaves显示文摘 | ALA P YANG DSC | 1992 | Plant Physiol1992，100，2： | 1 |
| 5 | Outcome of Henoch - SchSnlein nephritis with nephritic -range proteinuria 显示文摘 | Ronkainen J Ala - Houhala M Huttunen NP | 2003 | Clin Nephrol2003，60，2： | 1 |
| 6 | Antifreeze protein produced endogenously in winter rye leaves显示文摘 | Grifllth M Ala P Yang D S C | 1992 | Plant Physical1992，100，2： | 1 |
| 7 | Dextromethorphan metabolic phenotyping in an Iranian population显示文摘 | Afshar M Rouini M Ala S | 2005 | EurJ Clin Pharmaeol2005，60，12： | 1 |
| 8 | Evaluation ofradiated EMI in 42-V vehicle electrical systems by FDTDsimulation显示文摘 | Ala G Di Piazza M C Tine G | 2007 | IEEE Transactions on VehicularTechnology2007，56，4： | 1 |
| 9 | Response of antioxidant enzymes to transfer from elevated carbon dioxide to air and ozone fumigation, in the leaves and roots of wild-type and a catalase-deficient mutant of barley 显示文摘 | Azevedo S A Alas R M Smith R J | 1998 | Physiol Plant1998，104，： | 1 |
| 10 | Zinc and copper plasma concentrations in rheumatoid arthritis patients from a selected population in Iran Pak 显示文摘 | Ala S Shokrzadeh M Pur Shoja AM | 2009 | Pak J Biol Sci2009，12，14： | 1 |
| 11 | Modified LDL-trigger of atherosclerosis and inflammation in the arterial intima显示文摘 | PENTIKAINEN M O OORNI K ALA K | 2000 | J Intern Med2000，247，： | 1 |
| 12 | A simulation model for electromagnetic transients in lightning protection systems显示文摘 | Ala G Silvestre M L D | 2002 | IEEE Transactions on Electromagnetic Compatibility2002，44，4： | 1 |
| 13 | The FDS-property and spaces in which compact sets are closed显示文摘 | ALAS O T TKACHENKO M G TKACHUK V V | 2005 | Scientiae Mathematicae Japonicae2005，61，3： | 1 |
| 14 | Meta-analysis of the predictive value of KRAS mutations in treatment response using cetuximab in cohorectal cancer显示文摘 | Tsm&alas N Tzovaras AA Tolia M | 2012 | J BUON2012，17，1： | 1 |
| 15 | The role of clinical pharmacists in the improvement of a pharmacovigilance system: a review of the reported adverse drug reactions during 2004- 2010 in Mazandaran Province of Iran显示文摘 | Salehifar E Ala S Amini M | 2013 | Journal fPharmaceutical Care2013，1，1： | 1 |
| 16 | Early mobilization of acute stroke patients显示文摘 | Alas M Smith LN | 2007 | J Clin Nurs2007，16，2： | 1 |
| 17 | BNP as a biomarker in heartdisease显示文摘 | Vuolteenaho O Ala Kopsala M Ruskoaho H | 2005 | Adv Clin Chem2005，40，1： | 1 |
| 18 | Wavelet-based efficient simulation of electromagnetic transients in a lightning protection system显示文摘 | Ala G Silvestre M L D Francomano E | 2003 | IEEE Transactions on Magnetics2003，39，3： | 1 |
| 19 | BNP as a biomarker in heart disease显示文摘 | Vuolteenaho O Ala - Kopsala M Ruskoaho H | 2005 | Adv Clin Chem2005，40，： | 1 |
| 20 | Evaluation of radiated EMI in 42-V vehicle electrical systems by FDTD simulation 显示文摘 | ALA G DI PIAZZA M C TINE G | 2007 | IEEE Transactions on Vehicular Technology2007，56，4： | 1 |
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