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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 3 | Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm显示文摘AIM:To evaluate the feasibility and the outcome of endoscopic mucosal resection(EMR)for large colorectal tumors exceeding 4 cm(LCRT)undergoing piecemeal resection. METHODS:From January 2005 to April 2008,146 digestive tumors larger than 2 cm were removed with the EMR technique in our department.Of these,34 tumors were larger than 4 cm and piecemeal resection was carried out on 26 colorectal tumors.The mean age of the patients was 71 years.The mean follow-up duration was 12 mo. RESULTS:LCRTs were located in the rectum,left colon,transverse colon and right colon in 58%,15%, 4%and 23%of cases,respectively.All were sessile tumors larger than 4 cm with a mean size of 4.9 cm (4-10 cm).According to the Paris classification,34%of the tumors were typeⅠs,58%typeⅡa,4%typeⅡb and 4%typeⅡc.Pathological examination showed tubulous adenoma in 31%,tubulo-villous adenoma in 27%,villous adenoma in 42%,high-grade dysplasia in38%,in situ carcinoma in 19%of the cases and mucosal carcinoma(m2)in 8%of the cases.The two cases(7.7%)of procedural bleeding that occurred were managed endoscopically and one small perforation was treated with clips.During follow-up,recurrence of the tumor occurred in three patients(12%),three of whom received endoscopic treatment. CONCLUSION:EMR for tumors larger than 4 cm is a safe and effective procedure that could compete with endoscopic submucosal dissection,despite providing incomplete histological assessment. | Philippe Ah Soune Charles Ménard Ezzedine Salah Ariadne Desjeux Jean-Charles Grimaud Marc Barthet | 2010 | World Journal of Gastroenterology2010，16，5： | 4 |
| 4 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 5 | Sedentary behaviours and epithelial ovarian cancer risk显示文摘 | Zhang M Xie X Lee AH | 2004 | Cancer Causes Control2004，15，1： | 2 |
| 6 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 7 | 奈必洛尔和缬沙坦固定剂量联合治疗高血压的疗效与安全性研究显示文摘任意2类降压药物固定剂量联合降压作用强于单独增加一类药物剂量的作用。该研究评估β受体阻滞剂奈必洛尔(nebivolol)和血管紧张素受体拮抗剂缬沙坦(valsartan)固定剂量联合治疗成人高血压的疗效与安全性。方法:研究人员在美国401个医疗中心进行了为期8周、临床试验3期、多中心、随机、双盲、安慰剂平行对照试验。参与者均为≥18岁的高血压患者(但血压≤180/110mm Hg,1mm Hg=0.133kPa),以15例为一治疗组, | 刘莉 叶鹏 Giles TD Weber MA Basile J Gradman AH Bharucha DB Chen W Pattathil M | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 8 | Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ显示文摘 | Wagner AH Schwabe O Hecker M | 2002 | Br J Pharmacol2002，136，1： | 1 |
| 9 | Preliminary results of staged anterior debridement and reconstruction using titanium mesh cages in the treatment of thoracolumbar vertebral osteomyeli- tis显示文摘 | Fayazi AH Ludwig SC Dabbah M etal | 2004 | Spine J2004，4，4： | 1 |
| 10 | Markers of inflammation and coronary artery disease显示文摘 | Salam M Moh'd AH Gordon AF | 2002 | Med Sci Monit2002，8，1： | 1 |
| 11 | Normalization of retinal vascular permeability in experimental diabetes with genistein显示文摘 | Nakajima M Cooney MJ Tu AH | 2001 | Invest Ophthalmol Vis Sci2001，42，9： | 1 |
| 12 | Influenza virus overcomes apoptosis by rapid multiplication显示文摘 | Kurokawa M Koyama AH Yasuoka S | 1999 | Int J Mol Med1999，3，： | 1 |
| 13 | Identification,cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human显示文摘 | Hart AH Hartley L Ibrahim M | 2004 | Dev Dyn2004，230，1： | 1 |
| 14 | An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin ( Exubera) with mefformin as adjuctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea显示文摘 | Barnett AH Dreyer M Lange P | 2006 | Diabetes Care2006，29，6： | 1 |
| 15 | Identification, cloning and expression analysis of the pluripotency promoting nanog genes in mouse and human显示文摘 | Hart AH Hartley L Ibrahin M | 2004 | Dev Dyn2004，230，1： | 1 |
| 16 | Preterm lung function after retreatment with antenatal beta - methasone in preterm lambs显示文摘 | Polk DH Ikegami M Jobe AH | 1997 | Am J Obstet Gynecol1997，176，2： | 1 |
| 17 | Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases 显示文摘 | Garcia--Cao M O'Sullivan R Peters AH | 2004 | Nat Genet2004，36，1： | 1 |
| 18 | Retention of fiber posts cemented at different time intervals in canals obturated using an epoxy resin sealer 显示文摘 | Vano M Cury AH Goracci C | 2008 | J Dent2008，36，10： | 1 |
| 19 | Explaining development and change in organizations 显示文摘 | Van de Ven AH Poole M S | 1995 | Academy of Management Review1995，20，3： | 1 |
| 20 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
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