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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | 强化降压治疗期间估算的肾小球滤过率初始降低与长期肾功能:收缩压干预试验与控制糖尿病患者心血管病风险行动研究-血压随机对照试验的事后分析显示文摘血压降低可导致估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)的初始下降,但eGFR降低多少可以接受仍存在争议。研究人员对控制糖尿病心血管病风险行动(action to control cardiovascular risk in diabetes,ACCORD)-血压研究及收缩压干预试验(systolic blood pressure intervention trial,SPRINT)进行事后分析,两项研究均随机将患者分为强化或标准收缩压靶目标治疗。 | 赵狄(译) 刘莉(校) Collard D Brouwer TF Engberink RHGO Zwinderman AH Vogt L Born BJH | 2020 | 中华高血压杂志2020，28，5： | 3 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | Physical activity and breast cancer risk among Asian-American women in LosAngeles: a case-control study显示文摘 | Yang D Bernstein L Wu AH | 2003 | Cancer2003，97，107： | 2 |
| 5 | The third helix of the Antennapedia homeodomain translocates through biological membranes显示文摘 | Derossi D Joliot AH Chassaing G | 1994 | J Biol Chem1994，269，10： | 1 |
| 6 | Bowel wall thickening in patients with Crohn's disease: CT patterns and correlation with inflammatory activity显示文摘 | Choi D Jin LS Ah CY | 2003 | Clin Radiol2003，58，： | 1 |
| 7 | Markers of inflammation and coronary artery disease显示文摘 | Salam M Moh'd AH Gordon AF | 2002 | Med Sci Monit2002，8，1： | 1 |
| 8 | A comparison of five rapid direct toxicity assessment methods to determine toxicity of pollutant s to active sludge显示文摘 | Dalzell D J B Ahes Aspichueta E | 2002 | Chemosphere2002，47，： | 1 |
| 9 | Primary seminal vesicle carcinoma: an immunohistochemical analysis of four cases显示文摘 | Ormsby AH Haskell R Jones D | 2000 | Mod Pathol2000，13，1： | 1 |
| 10 | The protective effect of quercetin against oxidative stress in the human RPE in vitro显示文摘 | Kook D Wolf AH Yu AL | 2008 | Invest Ophthalmol Vis Sci2008，49，4： | 1 |
| 11 | Determinants of the Middle Cerebral Artery Peak Systolic Velocity in the Human Fetus显示文摘 | Picklesimer AH Oepkes D Moise KJ | 2007 | Am J Obstetrics Gynecol2007，197，5： | 1 |
| 12 | Evaluation of the use of monoclonal antibodies and nested PCR for noninvasive prenatal diagnosis of hemoglobinopathies in India显示文摘 | D′Souza E Sawant PM Nadkarni AH | 2008 | Am J Clin Pathol2008，130，86： | 1 |
| 13 | Evaluating health- related quality of life studies in paediatric populations: Some conceptual, methodological and developmental considerations and recent applications 显示文摘 | De Civita M Regier D Alamgir AH | 2005 | Pharmaco Economics2005，23，7： | 1 |
| 14 | CFD modelling of air-fired and oxy-fuel combustion of lignite in a 100 kW furnace 显示文摘 | A1-Abbas AH NASER J DODDS D | 2011 | Fuel2011，90，5： | 1 |
| 15 | Adenocarcinoma of the cecum: natural history and clinical patterns of recurrence following radical surgery 显示文摘 | Tong D Russell AH Dawson LE | 1983 | Int J Radiat Oncol Biol Phys1983，9，： | 1 |
| 16 | Plasma free 25- hydroxyvitamin D, vitamin D binding protein, and risk of breast cancer in the Nurses' Health Study II显示文摘 | Wang J Eliassen AH Spiegelman D | 2014 | Cancer Causes Control2014，25，： | 1 |
| 17 | Cognitive dysfunction and its relationship to quality of life in breast cancer survivors显示文摘 | Von Ah D Russell K M Storniolo A M | 2009 | Oncol Nurs Forum2009，36，3： | 1 |
| 18 | heterotopic ossification显示文摘 | Shehab D Elgazza AH Collier BD | 2002 | J Nucl Med2002，43，： | 1 |
| 19 | Options in the management of esophageal perforation:analysis over a 12-year period显示文摘 | Vallbohmer D Hlseher AH Holseher M | 2010 | Dis Esophagus2010，23，3： | 1 |
| 20 | Laser-induced mutual transposition of the core and the shell of a Au @ Pt nanosphere显示文摘 | Ah C S Kim S J Jang D J | 2006 | J Phys Chem B2006，110，11： | 1 |
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