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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomized, placebo-controlled trial显示文摘 | HOLDAAS H FELLSTROM B JARDINE AG | 2003 | Lancet2003，361，9374： | 1 |
| 4 | Preoperative chemotherapy for osteogenic sarcoma:selection of postoperative adjuvant chemotherapy based on the response of the primary tumor top reoperative chemotherapy显示文摘 | Rosen G Caparros B Huvos AG | 1982 | Cancer1982，49，6： | 1 |
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| 6 | Self - association and chaperone activity of Hsp27 are thermally activated 显示文摘 | Lelj - Garolla B Mauk AG | 2006 | J B iol Chem2006，281，12： | 1 |
| 7 | Heritability estimates for psychotic disorders: the Maudsley twin psychosis series显示文摘 | Cardno AG Marshall EJ Coid B | 1999 | Areh Gen Psychiatry1999，56，2： | 1 |
| 8 | Functional connectivity in the motor cortex of resting human brain using echoplanar MRI 显示文摘 | Biswal B Hudetz AG Yetkin FZ | 1995 | Magn Reson Med1995，34，： | 1 |
| 9 | Fluvastatin prevents cardiac death and myocardial infarction in renal transplant recipients : post-hoc subgroup analyses of the ALERT study显示文摘 | JARDINE AG HOLDAAS H FELLSTROM B | 2004 | Am J Transplant2004，4，6： | 1 |
| 10 | GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress 显示文摘 | Vairapandi M Balliet AG Hoffman B | 2002 | J CellPhysiol2002，192，： | 1 |
| 11 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI显示文摘 | Biswal B Hudetz AG Yetkin FZ | 1995 | Magn Reson Med1995，34，4： | 1 |
| 12 | Osteoarthritis of the knee: isokinetic quadriceps exercise versus an educational inter- vention显示文摘 | Maurer BT Stern AG Kinossian B | 1999 | Arch Phys Med Rehabil1999，80，10： | 1 |
| 13 | Bacteria-host com- munication: the language of hormones显示文摘 | Sperandio V Torres AG Jarvis B | 2003 | Proc Natl Acad Sci U S A2003，100，15： | 1 |
| 14 | Evolution and distribution of the ospC Gene, a transferable serotype of Borrelia burgdorferi显示文摘 | Barbour AG Travinsky B | 2010 | MBio2010，1，4： | 1 |
| 15 | The history of Toll-like receptors - redefin- ing innate immunity 显示文摘 | LA O D G AG B | 2013 | Nature Reviews Immunology2013，13，6： | 1 |
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| 17 | Discovery of Metaflumizone,a Novel Semicarbazone Insecticide显示文摘 | TA K AG I A K H A M AG U C H I B H N I S H I M AT S U B T | 2007 | Vet Parasitol2007，150，： | 1 |
| 18 | Magnetic Resonance Imaging of Sacroilitis in Early Seronegative Spondy larthropathy, Abnormalitiescorrelated to Clinical and Laboratory Findings显示文摘 | Puhakka KB Jurik AG Schiottz-Christensen B | 2004 | Rheumatology2004，43，2： | 1 |
| 19 | Complications of in- trathecal baclofen pump therapy in pediatric patients 显示文摘 | Borowski A Littleton AG Borkhuu B | 2010 | J Ped- iatr Orthop2010，30，1： | 1 |
| 20 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
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