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| 1 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 2 | Air pollution and brain damage显示文摘 | Calderon-Garcidueas L Azzarelli B Acuna H | 2002 | Toxicol Pathol2002，30，3： | 1 |
| 3 | Supervisory control at Salvador flotation columns 显示文摘 | Bergh L G Yianatos J B Acuna C A | 1999 | Minerals Engineering1999，12，7： | 1 |
| 4 | Air pollution and brain damage 显示文摘 | CALDERON-CARC1DUENAS L AZZARELLI B ACUNA H | 2002 | Toxieol Pathol2002，30，3： | 1 |
| 5 | Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome显示文摘 | Garcia Acuna JM Gonzalez-Babarro E Gfigofian Shamagian L | 2009 | Rev Esp Cardiol2009，62，5： | 1 |
| 6 | Air pol- lution and brain damage 显示文摘 | Calderon-Garciduenas L Azzarelli B Acuna H | 2002 | Toxicol Pathol2002，30，3： | 1 |
| 7 | Water use efficiency and associated physiological traits of nine naturalized white clover populations in Chile显示文摘 | Inostroza L Acuna H | 2010 | Plant Breeding2010，129，： | 1 |
| 8 | Quantification of aflatoxins in corn distributed in the city of Monterrey, Mexico 显示文摘 | TORRES ESFINOSA E ACUNA ASKAR K NACCHA TORRES L R | 1995 | Food Addit Contain1995，12，3： | 1 |
| 9 | Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome显示文摘 | Garcia Acuna JM Gonzalez-Babarro E Grigorian Shamagian L | 2009 | Rev Esp Cardiol2009，62，5： | 1 |
| 10 | Ecological functioning of the Iberian seas: A synthesis of GLOBEC research in Spain and Portugal 显示文摘 | ECHEVARRIA F ACUNA J L SAIZ E | 2007 | Progress in Oceanography2007，74，23： | 1 |
| 11 | Reconnaissance of selected PPCP compounds in Gosta Rican surface waters显示文摘 | Alison L Spongberg Jason D Witter Jenaro Acuna | 2011 | Water Research2011，45，： | 1 |
| 12 | Appendicularian assemblages in a shelf area and their relationship with temperature显示文摘 | Acuna J L Anadon R | 1992 | J Plankton Res1992，14，9： | 1 |
| 13 | The seasonal succession of appendicularians (Tunicata:Appendicularia) off Plymouth显示文摘 | Acuna J L Bedo A W Harris R P | 1995 | J Mar Biol Assoc U K1995，75，3： | 1 |
| 14 | Improved Active PowerFilter Performance for Renewable Power Generation Systems显示文摘 | Acuna P Morán L Rivera M | 2014 | IEEE Transactions on Power Electronics2014，29，2： | 1 |
| 15 | Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome 显示文摘 | Garcia Acuna JM Gonzalez-Babarro E Grigorian Shamagian L | 2009 | Rev Esp Cardiol2009，62，5： | 1 |
| 16 | Polarographic behaviour of aceclofenac,tenoxicam and droxicam in a methanolwater mixture显示文摘 | Acuna JA Vázquez M D Tascón M L | 2004 | J Pharm Biomed Anal2004，36，1： | 1 |
| 17 | Synthesis of Ni-Mo-W sulphide catalysts by ex situ decomposition of trimetallic precusors显示文摘 | HUIRACHE ACUNA R ALBITER M A ESPINO J ORNELAS C ALONSO G PARAGUAY DELGADO F RICO J L MARTINEZSANCHEZ R | 2006 | ppl Catal A2006，304，： | 1 |
| 18 | Perioperativevariables associated with surgical site infection in breastcancer surgery显示文摘 | Angarita FA Acuna SA Torreqrosa L | 2011 | J Hosp Infect2011，79，4： | 1 |
| 19 | Eduvascular therapy in the management of moderate and massive hemoptysis 显示文摘 | Poyanli A Acunas B Rozanes L | 2007 | Br J Radiol2007，80，953： | 1 |
| 20 | Palliation of malignantesophageal strictures with self-expanding nitinol stents: drawbacksand complications显示文摘 | Acunas B Rozanes l Akptnar S | 1996 | Radiology1996，199，3： | 1 |
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