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| 1 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 4 | Plant FtsZ1 and FtsZ2 expressed in a eukaryotic host: GTPase activity and self-assembly显示文摘 | Aaron G S Carol B J Stanislav V et ol | 2010 | FEBS letters2010，584，1： | 1 |
| 5 | What is normal? Female lower limb kinematic profiles during athletic tasks used to examine anterior cruciate ligament injury risk: A systematic review 显示文摘 | Aaron S Bonacci J Scott G | 2014 | Sports Med2014，44，10： | 1 |
| 6 | Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins显示文摘 | Lester G Aaron RK Neame P | 2002 | J Orthop Res2002，20，1： | 1 |
| 7 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 8 | Infant and young child feeding practices in urban Philippines and their associations with stunting, anemia, and deficiencies of iron and vitamin A 显示文摘 | Rohner F Woodruff BA Aaron G J | 2013 | Food Nutr Bull2013，34，2： | 1 |
| 9 | Synthesis of High Aspect Ratio Quantum- size CdS Nanorods and Their Surface-dependent Photoluminescence 显示文摘 | Aaron E S Ali G Preeti S | 2008 | Langmuir2008，24，： | 1 |
| 10 | Structural and near-IR photophysical studies on ternary lanthanide complexes containing poly(pyrazolyl)borate and 1,3-diketonate ligands显示文摘 | DAVIES G M AARONS R J MOTSON G R | 2004 | Dalton Trans2004，8，： | 1 |
| 11 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 12 | Uniform coverage of automotive surface patches显示文摘 | PRASAD N. A AARON G CONNER D. C CHOSET H ALFRED A.R | | 0，，11： | 1 |
| 13 | Improved methods for the ,cxtraction and analysis of isoflavones from soycontaining foods and nutritional suftplements by reversed-phase high-performance liquid chromatography and liquid chromatographymass spectrometry 显示文摘 | Aaron P G Mark W C | 2001 | Journal of Chromatography A2001，913，： | 1 |
| 14 | Ultrasound increases the rate of bacterial cell growth显示文摘 | Pitt Willam G Ross S Aaron | 2003 | Biotechnol Progr2003，19，3： | 1 |
| 15 | Nuclear constraints on the moments of inertia of neutron stars显示文摘 | Aaron W Plamen G K Li B A | 2008 | Astrophys J2008，685，390： | 1 |
| 16 | Evidence- based practice implementation: the impact of public versus private sector organization type on organizational support, provider atti- tudes, and adoption of evidence-based practice显示文摘 | Aarons G A Sommerfeld D H Walrath-Greene C M | 2009 | Implement Sci2009，，4： | 1 |
| 17 | Enduring effect of chronic corticosterone treatment on spatial learning,synaptic plasticity,and hippocampal neuropathology in young and mid-aged rats显示文摘 | SHARI R B AARON G H JEMMIFER C L | 1995 | J Neurosci1995，15，1： | 1 |
| 18 | Classification and Characteriza-tion of Heterotrophie Microbial Communities on the Basis of Patterns of Community-level Sole-carbon-source Utiliza- tion 显示文摘 | JAY L G AARON L M | 1991 | Applied and Environmental Microbiology1991，57，8： | 1 |
| 19 | Multiplexed toxin analysis using four colors of quantum dot fluororeagents 显示文摘 | Ellen R G Aaron R C George P A | 2004 | Anlytical Chemistry2004，76，： | 1 |
| 20 | Incorporating physiological and biochemical mechanisms into pharmacokinetic- pharmacodynamic models: a conceptual framework显示文摘 | Dahl S G Aarons L Gundert-Remy U | 2010 | Basic Clin Pharmacol Toxicol2010，106，1： | 1 |
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