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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Emerging concepts in liver graft preservation显示文摘The urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion(MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures(hypothermia at 4 ℃, normothermia a t 3 7 ℃ and subnormothermia at 20 ℃- 2 5 ℃). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the 'state of the art' and future perspectives in static and dynamic liver graft preservation in order to improve graft viability. | Mohamed Bejaoui Eirini Pantazi Emma Folch-Puy Pedro M Baptista Agustín García-Gil René Adam Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，2： | 5 |
| 4 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 5 | Isolation of transmissible enteritis agent of turkeys in avian embryos 显示文摘 | Adams N R Hofstad M S | 1971 | Avian Dis1971，15，： | 1 |
| 6 | Hydroch|orina tion of acetylene using carbon-supported gold cata- lysts:A study of catalyst reactivation显示文摘 | Bongani N Adams M D Neil ] C | 1991 | Journal of Catalysis1991，，37： | 1 |
| 7 | Streaming eovariance selection with applications to adaptive querying in sensor networks 显示文摘 | Anagnostopoulos C Adams N M Hand D J | 2010 | Computer Journal2010，53，9： | 1 |
| 8 | Elecrochemical corrosion of an Al-Mg-Cr-Mn alloy containing Fe and Si inhibited alkaline solutions显示文摘 | ADAM A M M M BORRAS N PEREZ E | 1996 | Journal of Power Sources1996，58，： | 1 |
| 9 | Microstrueture of dense thin sheets of γ-TiAl fabricated by hot isostatic pressing of tape-cast monotapes 显示文摘 | ADAMS A G RAHAMAN M N DUTTON R E | 2008 | Materials Science and Engineering2008，447，： | 1 |
| 10 | Hashimo- tos thyroiditis following Graves'disease 显示文摘 | UMAR H MUALLIMA N ADAM J M | 2010 | Acta Med In- dones2010，42，1： | 1 |
| 11 | Human pathogenic viruses at sewage sludge disposal sites in the Middle Atlantic region 显示文摘 | GOYAL S M ADAMS W N OMALLEY M L | 1984 | Appl Environ Microbiol1984，48，： | 1 |
| 12 | Support services for survi- vors of ebola virus disease -Sierra Leone,2014显示文摘 | Lee-Kwan SH DeLuca N Adams M | 2014 | Morb Mortal Wldy Rep2014，63，50： | 1 |
| 13 | Characteristics of the microplate method of enzyme - linked immunosorbent assay for the detection of plant viruses显示文摘 | Clark M F Adams A N | 1977 | Journal of Genernal Virology1977，34，： | 1 |
| 14 | Atmospheric forcing of the southeast Bering Sea Shelf during 1995-99 in the context of a 40-year historical record显示文摘 | Bond N A Adams J M | 2002 | Deep-Sea Research2002，49，： | 1 |
| 15 | Semiparametric approaches to stochastic panel frontiers with applications in the banking industry显示文摘 | Robert M Adams Allen N Berger Robin C Sickles | 1999 | Journal of Business and Economic Statistics1999，17，3： | 1 |
| 16 | Smoke-free cafe in an unregulated European city: highly welcomed and economically successful 显示文摘 | Ktinzli N Mazzoletti P Adam M | 2003 | Tobacco Control2003，12，： | 1 |
| 17 | Hashimoto's thyroiditis following Graves' disease显示文摘 | UMAR H MUALLIMA N ADAM J M | 2010 | Aeta Med Indones2010，42，1： | 1 |
| 18 | Computational Social Science显示文摘 | Lazer D Pentland A Adamic L Aral S Barabasi A L Brewer D Christakis N Contractor N Fowler J Gutmann M Jebara T King G Macy M Roy D Van Alstyne M | | 0，，5915： | 1 |
| 19 | The effects of surface pretreatment on the cyclic-fatigue characteristics of bonded aluminium-alloy joints 显示文摘 | ABEL M L ADAMS A N KINLOCH A J | 2006 | International Journal of Adhesion & Adhesives2006，26，： | 1 |
| 20 | Nitric oxide-mediated regulation of chemosensitivity in cancer cell显示文摘 | Matthews N E Adams M A Maxwell L R | 2001 | J Natl Cancer Inst2001，93，24： | 1 |
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