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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Non-functional neuroendocrine tumors of the pancreas: Advances in diagnosis and management显示文摘Nonfunctional neuroendocrine tumors of the pancreas(NF-PNETs) are a heterogeneous group of neoplasms. Although rare, the incidence of NF-PNETs is increasing significantly. The classification of PNETs has evolved over the past decades and is now based on a proliferation grading system. While most NF-PNETs are slow growing, tumors with more aggressive biology may becomeincurable once they progress to unresectable metastatic disease. Tumors of higher grade can be suspected preoperatively based on the presence of calcifications, hypoenhancement on arterial phase computed tomography, positron emission technology avidity and lack of octreotide scan uptake. Surgery is the only curative treatment and is recommended for most patients for whom complete resection is possible. Liver-directed therapies(thermal ablation, transarterial embolization) can be useful in controlling unresectable hepatic metastatic disease. In the presence of unresectable progressive disease, somatostatin analogues, everolimus and sunitinib can prolong progression-free survival. This article provides a comprehensive review of NF-PNETs with special emphasis on recent advances in diagnosis and management. | Jordan M Cloyd George A Poultsides | 2015 | World Journal of Gastroenterology2015，21，32： | 11 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | The precautionary principle in contemporary environmental polities显示文摘 | O' Riordan T Jordan A | 1995 | Environ Values1995，4，： | 2 |
| 5 | Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival显示文摘 | A Jawhari S Jordan S Poole P Browne M Pignatelli MJ Farthing | 1997 | Gastroenterology1997，，1： | 2 |
| 6 | Coralline hydroxyapatite orbital implant(bio-eye): experience with 158 patients显示文摘 | Jordan D R Gilberg S Bawazeer A | 2004 | Ophthal Plast Reconstr Surg2004，20，1： | 1 |
| 7 | Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation显示文摘 | Jordan M Schallhorn A Wurm FM | 1996 | Nucleic Acids Res1996，24，： | 1 |
| 8 | Randomized phase 1I trial of capecitabine plus irinotecan(Caplri) vscapecitabine plus oxaliplatin (CapOx) as first-line therapy of advanced colorectal cancer(ACRC) 显示文摘 | Grothey A Jordan K Keller O | 2003 | Proc Am Soc Clin Oncol2003，22，： | 1 |
| 9 | Categorizing the severity of neck pain: establishment of cut- points for use in clinical and epidemiological re- search显示文摘 | Fejer R Jordan A Hartvigsen J | 2005 | Pain2005，119，： | 1 |
| 10 | Latent dirichlet allocation显示文摘 | Blei D Ng A Jordan M | 2003 | Journal of Machine Learning Research2003，3，1： | 1 |
| 11 | Cel ular uptake of magnetic fluid particles and their effects on human adenocarcinoma cel s exposed to AC magnetic fields in vitro显示文摘 | Jordan A Wust P Scholz R | | 0，，06： | 1 |
| 12 | Obstructive sleep apne- a: Plasma endothelin-1 precursor but not endothelin-1 levels are elevated and decline with nasal continuous positive airway pressure 显示文摘 | Jordan W Reinbacher A Cohrs S | 2005 | Peptides2005，26，： | 1 |
| 13 | Adult obstructive sleep apnoea 显示文摘 | Jordan AS McSharry DG Malhotra A | 2014 | Lancet2014，383，9918： | 1 |
| 14 | The evolution of speed,size and shape in modern athletics显示文摘 | JORDAN D BEJAN A | 2009 | J Exp Biol2009，212，： | 1 |
| 15 | Breeding crop varieties for stress envi- ronments显示文摘 | Blum A Jordan W R | 1985 | Critical Reviews in Plant Sciences1985，，19： | 1 |
| 16 | Latent Dir/chlet allocation显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | Journal of Machine Learning Research2003，3，： | 1 |
| 17 | Latent Dirichlet Allocation 显示文摘 | BLEI D M NG A Y JORDAN M I | 2003 | the Journal of Machine Learning Research2003，，3： | 1 |
| 18 | Effect of harvest maturity,storage,and cultivar on strawberry fruit aroma volatiles显示文摘 | FORNEY C F JORDAN M A | 1995 | HortScience1995，30，： | 1 |
| 19 | Effect of organic sulfonic acids as catalysts during phenol liquefaction of Pinus radiata bark显示文摘 | MUN S P GILMOUR I A JORDAN P J | 2006 | Journal of Industrial and Engineering Chemistry2006，12，5： | 1 |
| 20 | Thymic selection of CD4+CD25 + regulatory T cells induced by an agonist self-peptide显示文摘 | Jordan MS Boesteanu A Reed AJ | 2001 | Nature Immunol2001，2，4： | 1 |
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